PubMed offers what they call an "alert" facility. It allows you to save a search, and then PubMed will automatically notify you once new entries match that search. It's wonderfully convenient, and ensures that you always have the latest information.
Anyway, today's alert included two new studies that investigated the effect of circumcision against genital herpes.
Jerath and Mahajan performed a fairly small study, but an interesting one. Their study population consisted of forty patients with recurrent genital herpes. Half were circumcised, half were not, and all (except 12 drop outs) were monitored afterwards. What they found was rather interesting. Prior to circumcision, 0.20 recurrences were noted per year, which is similar to the 0.17 that was recorded in the (uncircumcised) control group. But after circumcision, this fell to 0.0080 recurrences per year - a startling decrease to a mere 4% of the pre-circumcision figure. Now this is a small study, and as far as I can tell there was no randomisation process, but nevertheless the results are interesting.
Also of interest is a study by Van Wagoner et al. This was a fairly straightforward study of 460 African American heterosexual men. This study found an association between lack of circumcision and HSV-1 seroprevalence (OR: 1.85; CI: 1.15-2.96), but not HSV-2.