Tuesday 13 March 2012

Circumcision and prostate cancer

The journal Cancer has published a new study by Wright et al., entitled "Circumcision and the risk of prostate cancer".

It's an interesting read. It's a case-control study, with 1754 cases and 1645 age-matched controls, making it by far the largest study of prostate cancer and circumcision to date. 68.8% of cases were circumcised, compared with 71.5% of controls. The risk of prostate cancer was about 13% lower among circumcised men.

Complicating the issue somewhat was the timing of circumcision, as not all men had been circumcised at birth. The fact that some circumcised men had spent some of their lives with a foreskin obviously has an impact. Indeed, in the case of penile cancer the risk is actually greater in men circumcised after childhood, likely because such circumcisions tend to be associated with conditions such as phimosis and balanitis that themselves predispose towards penile cancer.

Wisely, the researchers performed sub-analyses taking into account the timing of circumcision. They found that men circumcised before first sexual intercourse had 15% lower risk of prostate cancer. Interestingly, there was a small difference in the type of cancer: the risk reduction was 12% for less aggressive forms and 18% for more aggressive types.

While not conclusive, this study is consistent with earlier studies that also found a protective effect against circumcision. My colleagues and I previously published cost analyses on circumcision vs prostate cancer.

Sunday 25 September 2011

Rebuttal to part 4...

Darcia Narvaez has posted part 4 of Cannon's series of articles about circumcision. Let's dive in.

No medical association in the world recommends routine infant circumcision. None.

Technically true, but routine infant circumcision means, literally, circumcision of all newborn boys. Consider what would justify such a recommendation: there would have to be an enormous net benefit to warrant taking such a decision out of the hands of parents.

In practice, most medical associations agree that the matter is suitable for parental choice.

Medicaid spends $198 million each year on routine infant circumcision in the 33 states that still pay for it, a procedure its own guidelines consider to be medically unnecessary. Private insurance programs are reimbursing an additional $677 million, raising prices for us all (Craig 2006.)

Actually, a CDC study was published in 2010 that found that "Newborn circumcision was a cost-saving HIV prevention intervention for all, black and Hispanic males". And that study considered only one benefit. If other benefits were to be considered as well, it would obviously be more cost-saving still.

Doctors have an ethical duty to treat the patient by the most conservative means possible, but removing healthy tissue in the absence of any medical need absolutely harms the patient.

By what logic? Cannon seems to think that asserting this claim is enough, but it isn't. Removal of tissue isn't inherently harmful; nor is it inherently beneficial. It can be either; to determine which the only rational approach is to look at the consequences.

Everyone has a right to bodily autonomy and self-determination. This is a fundamental tenet of international human rights law (UNESCO 2005).

Then it needs to be determined whether circumcision represents a significant violation. Human rights are not absolute, and are not intended to be read as such. Free expression, for example, does not give a person the right to libel another. Applying common sense, could it apply to something as trivial as a foreskin? It deems doubtful.

Parents' aesthetic preferences are not valid reasons for circumcision.

This statement makes sense only if one considers circumcision to be a bad thing that requires a lot of justification. But, since it is widely accepted that circumcision is harmless at worst and beneficial at best, that position seems unsupportable. Would it make sense to demand a valid reason for feeding a child a healthy diet?

If you have never had a foreskin, you cannot possibly know what having one would feel like. You only know what it feels like to not have a foreskin. You cannot know now how your son will feel in 20 or 30 years. If you have your son circumcised, he may grow up to regret the decision you made for him, but circumcision is irreversible. (Yes, men can partially restore their foreskins, but it is difficult and the sensitive nerve endings are gone forever.)

Conversely, if you don't have him circumcised, he might regret that, too. And adult circumcision is much riskier, requires a long period of abstinence, and results in inferior cosmetic results. There's no way to guarantee that he won't resent the decision, unfortunately.

Parents have a duty to educate themselves on circumcision rather than do it just because it was done to them.

For clear, easy and plain-language help making the circumcision decision, try the Circumcision Decision Maker at http://circumcisiondecisionmaker.com/.

That website recommends non-circumcision in virtually every case (the exception, as I recall, being for Orthodox Jews). If you've already decided not to circumcise and want an excuse, use it. Otherwise, it's not recommended.

Slavery and child labor were traditions sanctioned by religions and other authorities. But we abandoned those practices because they were unjust and harmful. Infant circumcision, similarly supported by authorities, should be abandoned by the people who care for children because it is unjust and harmful.

Except, of course, that it is neither unjust nor harmful. Asserting otherwise doesn't change the facts.

You were circumcised because your dad was circumcised because everyone else was circumcised because 140 years ago, some perverted doctors wanted to stop boys from masturbating.

Probably not, but I'm sure this is impressive propaganda.

Being circumcised isn't better, and it isn't popular anymore. The 70% of the world's men who have foreskins almost never choose to have them cut off and consider them to be the best part of the penis.

According to what research?

Circumcision is ending with the generation being born now - only 32% of babies born in 2009 in the USA were circumcised.

Actually, CDC data suggest that the figure is about 55%, and they caution that this is an underestimate. And, of course, rates vary greatly across the country.

Sunday 18 September 2011

Debunking myths, part 3

Cannon and Bollinger have released part 3 of their series of "myths" articles. As with previous parts, I'm analysing them here.

We'll skip the first three ("You have to circumcise the baby so that he will match his dad" and "My first son is circumcised, so I have to circumcise my second son" and "My husband is the one with the penis, so it is his choice"), since as presented they are close to myths.

Myth: Everyone is circumcised. Reality check: Actually, world-wide, only 30% of men are circumcised, and most of these men are Muslim (WHO 2007). Most modern, Westernized countries have rates well below 20%. In the United States about 25 years ago, around 85% of babies were circumcised. The rates have dropped substantially to 32% in 2009, according to a report by the Centers for Disease Control (El Becheraoui 2010).

Here the authors cite a 2010 conference presentation regarding data gathered in a survey that wasn't designed to measure circumcision rates. The New York Times quoted a CDC spokesperson as saying "we cannot comment on the accuracy of this particular estimate of infant male circumcision." Figures that the CDC have actually released are about 55%, but they caution that these underestimate the true rate.

Myth: Circumcision is an important tradition that has been going on forever. Reality check: In the United States, circumcision wasn't popularized until Victorian times, when a few doctors began to recommend it to prevent children from masturbating. Dr. Kellogg (of Corn Flakes fame) advocated circumcision for pubescent boys and girls to stop masturbation...

Ah, this old myth (and the obligatory Kellogg quote, too). No matter how striking it is, it's an error to conclude that circumcision arose because of Kellogg's recommendation. People advocate all kinds of things for all kinds of reasons. People in the late 19th century advocated circumcision for a variety of reasons, too. Gollaher, in his "Circumcision: a history of the world's most controversial surgery" devotes only a handful of pages to masturbation; he traces the history to a Lewis Sayre, who (oddly) believed circumcision could cure certain types of paralysis.

Myth: Circumcision makes sex better for the woman. and Myth: Women don't want to have sex with uncircumcised men. Reality check: In a landmark study of US women, 85% who had experienced both circumcised and intact men preferred sex with intact men.

Here the authors cite a study by O'Hara, which recruited most of the participants from an anti-circumcision mailing list, thus severely biasing the results. Credible studies, without such biases, find the opposite. See, for example, here.

Myth: "Being circumcised doesn't affect my sex life." Reality check: Men who are circumcised are 60% more likely to have difficulty identifying and expressing their feelings, which can cause marital difficulties (Bollinger 2010).

Here the authors cite an unpublished study by the second author.

Circumcised men are 4.5 times more likely to be diagnosed with erectile dysfunction, use drugs like Viagra, and to suffer from premature ejaculation (Bollinger 2010, Tang 2011).

Here the authors engage in cherry-picking. From memory, 3 studies have found increased risk of ED, 3 have found decreased risk, and six have found no statistically significant difference.

Men who were circumcised as adults experienced decreased sensation and decreased quality of erection, and both they and their partners experienced generally less satisfaction with sex (Kim 2007, Solinis 2007).

Again, the authors are engaging in cherry-picking. More studies report increased sensation than report decreased sensation, we've dealt with ED and partner satisfaction above. There is a reasonable summary of the research at Wikipedia.

Myth: "If I were any more sensitive, it would be a problem." Reality check: The foreskin contains several special structures that increase sexual pleasure, including the frenulum and ridged band (the end of the foreskin where it becomes internal), both of which are removed in circumcision. The LEAST sensitive parts of the foreskin are more sensitive than the MOST sensitive parts of the circumcised penis (Sorrells 2007).

Here the authors cite a flawed study by Sorrells et al. The authors arrived at this conclusion by testing their results for statistical significance and ignoring the result (see here). Interestingly, the authors only assessed the ability to sense the lightest touch; they did not test sensitivity to sexual stimulation. Schober et al did (admittedly with a small sample of uncircumcised men), and found that the foreskin is actually the least sexually sensitive part of the penis.

It may feel like the penis is overly sensitive to a circumcised man because there is little sensation left to indicate excitement, leading to unexpected premature ejaculation (a common problem with circumcised young men).

Actually more common among uncircumcised young men.

However, as circumcised penises age they become calloused and much less sensitive. (See the interview listed below for more details.)

Better still, see the peer-reviewed research which shows that the level of "callousing" (keratinisation) is the same in circumcised and uncircumcised men (see here), and that the glans penis is equally sensitive (see here, here, here and here).

Tuesday 13 September 2011

Debunking more "myths"

Earlier today I posted a rebuttal to the first part of a "myths" article. The second part has also been posted, and is just as bad. Let's dissect it:

I'm going to skip the first two items ("You have to get the baby circumcised because it is really hard to keep a baby's penis clean" and "Little boys won't clean under their foreskins and will get infections"), because as presented they're so extreme that they almost are myths. That said, it is easier to keep a circumcised penis clean (except for the brief healing period, of course), and uncircumcised penises are more prone to infections.

Myth: Uncircumcised penises get smelly smegma. Reality check: Actually, smegma is produced by the genitals of both women and men during the reproductive years. Smegma is made of sebum and skin cells and lubricates the foreskin and glans in men, and the clitoral hood and inner labia in women. It is rinsed off during normal bathing and does not cause cancer or any other health problems.

Actually, these are rather dubious statements. A few hypotheses have been proposed, but to date no evidence supports the notion that smegma has any biological function. What little evidence there is suggests that it is associated with penile inflammation, HIV, and with penile cancer. (I should note that this evidence isn't particularly strong.) In the case of penile cancer, for example, all three of the human studies to investigate found an association between smegma and penile cancer; see here.

Myth: "My uncle wasn't circumcised and he kept getting infections and had to be circumcised as an adult." Reality check: Medical advice may have promoted infection in uncircumcised males. A shocking number of doctors are uneducated about the normal development of the foreskin, and they (incorrectly) tell parents that they have to retract the baby's foreskin and wash inside it at every diaper change. [...]

The author elaborates further on this interesting hypothesis, but utterly fails to provide any evidence whatsoever. But there's a really simple way to test it. If the difference is due to lack of knowledge about the foreskin in countries with high prevalence of circumcision, then we'd expect that studies conducted in countries with low circumcision rates wouldn't see any difference. In fact, though, the difference is observed both in the US and Canada (both of which have relatively high percentages of circumcised men) and in the UK and New Zealand (both of which have relatively low percentages of circumcised men).

Myth: My son was diagnosed with phimosis and so had to be circumcised. Reality check: Phimosis means that the foreskin will not retract. Since children's foreskins are naturally not retractable, it is impossible to diagnose phimosis in a child. Any such diagnoses in infants are based on misinformation, and are often made in order to secure insurance coverage of circumcision in states in which routine infant circumcision is no longer covered.

While an interesting conspiracy theory, there's no evidence for this. Phimosis can be diagnosed at any age, partly because acquired phimosis tends to be characterised by the presence of whitish, hard scar tissue at the tip of the foreskin. It may be overdiagnosed in children, but to claim that it cannot be diagnosed is dangerously misinformed.

Myth: Uncircumcised boys get more urinary tract infections (UTIs.) Reality check: This claim is based on one study that looked at charts of babies born in one hospital (Wiswell 1985).

Wrong. There have been about 25 studies to date. See here for a partial list.

Myth: Circumcision prevents HIV/AIDS. Reality check: Three studies in Africa several years ago that claimed that circumcision prevented AIDS and that circumcision was as effective as a 60% effective vaccine (Auvert 2005, 2006). These studies had many flaws, including that they were stopped before all the results came in. There have also been several studies that show that circumcision does not prevent HIV (Connolly 2008).

Here the author is mistakenly treating all studies as equal. They aren't. The most rigorous studies are of a type called randomised controlled trials. The most important characteristic of these studies is that circumcision is performed as part of the study, and men are selected to be circumcised at random. A less rigorous (but much cheaper) study design is to look at men who've been circumcised previously, and see whether they're HIV positive or not. This design is called an observational study, and the main problem with it is that circumcision is often associated with something else (say, religion) that's also associated with behavioural differences. So it's difficult to tell whether circumcision, or these behavioural differences, are responsible.

Of about 50 or so observational studies to date, probably 40 have found a protective effect. All three randomised controlled trials did likewise.

Monday 12 September 2011

Debunking another "myths" article

Anti-circumcision authors seem to have a curious knack for writing articles that purportedly expose myths about circumcision while actually containing a number of incorrect statements. This is no exception. Let's dive in. (Note: I'm reformatting some of what follows for convenience.)

Myth 1: They just cut off a flap of skin. Reality check: Not true. The foreskin is half of the penis's skin, not just a flap. In an adult man, the foreskin is 15 square inches of skin. In babies and children, the foreskin is adhered to the head of the penis with the same type of tissue that adheres fingernails to their nail beds. Removing it requires shoving a blunt probe between the foreskin and the head of the penis and then cutting down and around the whole penis.

First, the average surface area of the foreskin is 36.8 square centimetres, which is 5.7 square inches not 15. Second, it's a gross exaggeration to liken the adhesions between the glans and foreskin to the nail bed. The foreskin and glans are primed to separate, and have often begun (though rarely completed) this process at birth. Separating the two is relatively trivial, requiring little force.

Myth 2: It doesn't hurt the baby. Reality check: Wrong. In 1997, doctors in Canada did a study to see what type of anesthesia was most effective in relieving the pain of circumcision. As with any study, they needed a control group that received no anesthesia. The doctors quickly realized that the babies who were not anesthetized were in so much pain that it would be unethical to continue with the study. Even the best commonly available method of pain relief studied, the dorsal penile nerve block, did not block all the babies' pain. Some of the babies in the study were in such pain that they began choking and one even had a seizure (Lander 1997).

Yes, circumcision without anaesthesia hurts. But the very study cited acknowledged that ring block was effective: "Of the 3 anesthetics considered in this investigation, ring block is clearly superior. It provides satisfactory anesthesia for all stages of the circumcision. While newborns fussed periodically over the restraints or being handled, they typically did not react to the most nociceptive elements of the circumcision (such as foreskin separation and incision)."

Myth 3: My doctor uses anesthesia. Reality check: Not necessarily. Most newborns do not receive adequate anesthesia. Only 45% of doctors who do circumcisions use any anesthesia at all. Obstetricians perform 70% of circumcisions and are least likely to use anesthesia - only 25% do. The most common reasons why they don't? They didn't think the procedure warranted it, and it takes too long (Stang 1998). A circumcision with adequate anesthesia takes a half-hour - if they brought your baby back sooner, he was in severe pain during the surgery.

The cited source (Stang and Snellman) is thirteen years old, and probably doesn't represent current practice very well. A more recent study found considerable differences in use of anaesthesia in only five years: 71% in 1998 and 97% in 2003.

Myth 4: Even if it is painful, the baby won't remember it. Reality check: The body is a historical repository and remembers everything. The pain of circumcision causes a rewiring of the baby's brain so that he is more sensitive to pain later (Taddio 1997, Anand 2000). Circumcision also can cause post-traumatic stress disorder (PTSD), depression, anger, low self-esteem and problems with intimacy (Boyle 2002, Hammond 1999, Goldman 1999). Even with a lack of explicit memory and the inability to protest - does that make it right to inflict pain? Law requires anesthesia for animal experimentation - do babies deserve any less?

There's no credible evidence that circumcision has any such long-term psychological effects. Claims to the contrary are entirely speculative, as can be seen by reading the cited sources.

Myth 5: My baby slept right through it. Reality check: Not possible without total anesthesia, which is not available. Even the dorsal penile nerve block leaves the underside of the penis receptive to pain. Babies go into shock, which though it looks like a quiet state, is actually the body's reaction to profound pain and distress. Nurses often tell the parents "He slept right through it" so as not to upset them. Who would want to hear that his or her baby was screaming in agony?

This "explanation" is amusingly contrived, but of course Occam's Razor favours the alternative explanation: that the baby actually did sleep through the procedure. This is perfectly consistent with studies of adult circumcision under anaesthesia, in which pain is reported by only a few men. For example, pain was reported by 0.83% of men in one study, and 0.2-0.3% in another.

Myth 6: It doesn't cause the baby long-term harm. Reality check: Incorrect. Removal of healthy tissue from a non-consenting patient is, in itself, harm (more on this point later). Circumcision has an array of risks and side effects. There is a 1-3% complication rate during the newborn period alone (Schwartz 1990). Here is a short list potential complications.

1-3% is a bit of an exaggeration. A recent systematic review found a median of 1.5%, but most are extremely minor.

This section continues:

Meatal Stenosis: Many circumcised boys and men suffer from meatal stenosis. This is a narrowing of the urethra which can interfere with urination and require surgery to fix.

While there's no proof, it seems likely that circumcision is a contributing factor to meatal stenosis. However, it's an exaggeration to say that "many" suffer. The largest study of circumcision and meatal stenosis found 7 cases in 66,519 circumcisions - 0.01%. The next two largest studies found risks of 0.9% (29 in 3,205) and 0.55% (11 in 2,000).

Adhesions. Circumcised babies can suffer from adhesions, where the foreskin remnants try to heal to the head of the penis in an area they are not supposed to grow on. Doctors treat these by ripping them open with no anesthesia.

As with uncircumcised boys, adhesions can occur. And, as with uncircumcised boys, they usually resolve without treatment. See this study.

(I'm skipping discussion of buried penis and infection. Both can occur, though the risk of each is small.)

Death. Babies can even die of circumcision. Over 100 newborns die each year in the USA, mostly from loss of blood and infection (Van Howe 1997 & 2004, Bollinger 2010).

This figure is wrong, as we've discussed previously.

Thursday 21 July 2011

Sexual satisfaction & circumcision: latest from IAS 2011

The International AIDS Society's 2011 meeting has now concluded, and — as is often the case these days — there some interesting presentations.

Of particular interest are two abstracts: Breda and Westercamp et al.

In Uganda, Breda reports on a study of 316 adult circumcision patients:
Compared to before circumcision, 87.7% (193/220) reported ease of reaching orgasm as “better”; 92.3% reported sexual satisfaction as “better”; 97.7% and 95.4% were satisfied with and thought their partners satisfied with their appearance, respectively.

In Kenya, Westercamp et al reported on a study of 1016 adult circumcision patients:
Men reported a higher overall level of satisfaction with intercourse after circumcision (71% vs. 87%, p< 0.0001). 54% of men reported their penis being much more sensitive and 36% reported reaching orgasm much more easily 6 months after circumcision.

Also, sexual dysfunctions (for two weeks or more) decreased:
inability to climax (20% vs. 16%, p=0.007), finding sex not pleasurable (31% vs. 24%, p=0.0005), and lack of interest in sex (45% vs. 39%, p=0.008).

And fewer penile traumas were reported (consistent with Mehta et al):
At 6 months, men reported experiencing fewer problems with reproductive health in the last 6 months compared to baseline: painful urination (10% before vs. 7%, p=0.008), difficulty passing urine (7% vs. 4%, p=0.01), and sores around genitals (7% vs. 4%, p=0.002). Similar reductions were found in measures of penile trauma in the preceding 6 months: pain during intercourse (15% vs. 8%, p< 0.0001); scratches, cuts, abrasions during sex (24% vs. 6%, p< 0.0001); and bleeding during or after intercourse (10% vs. 3%, p< 0.0001).

These studies add to the growing body of evidence showing that circumcision does not harm, and may well improve men's sexual experience.

As far as I can tell, neither study reports on RCT data; instead, both report on prospective study of patients circumcised as part of subsequent circumcision programmes in the same locations. Hopefully both studies will be published soon.

Tuesday 12 July 2011

The so-called "lost list"

Although less prominent these days, I still find that people occasionally cite the "lost list", seemingly unaware of its inaccuracies. For those unfamiliar with it, this is a list of structures or functions supposedly lost through circumcision.

A number of different versions can be found on the Internet, but they're very similar. The text below is taken from NORM-UK. My comments are in italics.

The Foreskin which comprises up to 50% (sometimes more) of the mobile skin system of the penis. If unfolded and spread out flat the average adult foreskin would measure about 15 square inches( the size of a 3x5 inch index card).

This is a gross exaggeration. First, one study has actually measured the surface area of the adult foreskin; it found an average surface area of 36.8 square centimetres (that's 5.7 square inches). (I previously stated that this was the only study. I was mistaken. A second study, with a small sample size, does exist. It reported an average surface area of 46.7 square centimetres, or 7.2 square inches.) Second, as I recently showed in my critique of Barefoot Intactivist's propaganda, it is reasonable to estimate that the foreskin constitutes 14% of the penile skin system. Using the surface area figure from Werker et al., that's 18% — still less than half of the extraordinary 50% figure.

This highly specialized tissue normally covers the glans and protects it from abrasion, drying, callusing (also called keratinization), and contaminants of all kinds.The effect of glans keratinisation has never been studied.

This sentence is dubious in many ways. The most obvious is the statement that the foreskin protects the glans from keratinisation — the only study in the literature to have examined keratinisation by circumcision status found no differences between the level of keratinisation of the circumcised and uncircumcised glans. Less obvious, but still troubling, is the implication that the circumcised glans is susceptible to abrasion or "contaminants". No evidence is cited in support.

[1. M. M. Lander, "The Human Prepuce," in G. C. Denniston and M. F. Milos, eds., Sexual Mutilations: A Human Tragedy (New York: Plenum Press, 1997), 79-81. 2. M. Davenport, "Problems with the Penis and Prepuce: Natural History of the Foreskin," British Medical Journal 312 (1996): 299-301.]

Note that only two sources are cited. One (Davenport) is peer-reviewed but does not support any of the claims attributed to it. The other (Lander) is a non-peer-reviewed paper presented at an anti-circumcision conference, which doesn't inspire confidence.

The Frenar Ridged Band, the primary erogenous zone of the male body.

When I see a claim like this, I immediately wonder: who established this, and what was the study methodology? The cited source (Taylor, see below) established nothing of the sort. While a small number of studies have investigated sensitivity to non-sexual stimulus, only one study, to my knowledge, has investigated the relative degree of sexual pleasure produced by various parts of the anatomy. That study (which was unfortunately limited by the small number of uncircumcised men) found that the foreskin actually produces the least sexual pleasure of any part of the penis.

Loss of this delicate belt of densely innervated, sexually responsive tissue reduces the fullness and intensity of sexual response.
[Taylor, J. R. et al., "The Prepuce: Specialized Mucosa of the Penis and Its Loss to Circumcision," British Journal of Urology 77 (1996): 291-295.]

Note that the cited source says nothing of the sort! Its authors merely "postulate" that the "ridged band" is sensory tissue. They don't attempt to prove it, nor do they evaluate the effects of its removal on the "fullness and intensity" of sexual response.

The Foreskin's 'Gliding Action' - the hallmark mechanical feature of the normal natural, intact penis. This non-abrasive gliding of the penis in and out of itself within the vagina facilitates smooth , comfortable, pleasurable intercourse for both partners. Without this gliding action, the corona of the circumcised penis can function as a oneway valve, scraping vaginal lubricants out into the drying air and making artificial lubricants essential for pleasurable intercourse.
[P. M. Fleiss, MD, MPH, "The Case Against Circumcision," Mothering: The Magazine of Natural Family Living (Winter 1997): 36-45.]

Note that the only source cited for this claim is an opinion piece published in a magazine. It's an interesting hypothesis, but little or no credible evidence supports it.

[Indented box] Nerve Endings transmit Sensations to the Brain - Fewer Nerve Endings means Fewer Sensations

This simplistic model is faulty because the presence of nerve endings do not create sensations by themselves. Likely as not, your genitals are not buzzing with sensations as you read this, because they're not being stimulated. This means that the method and degree of stimulation is as important as the number of nerve endings. Put simply, a smaller number of nerve endings can produce just as much stimulation as a larger number, if stimulated more effectively. And this is effectively what circumcision achieves, by exposing the glans (especially the sensitive corona) to direct stimulation during intercourse, sensation is increased, compensating for the loss of sensation from the foreskin itself.

Circumcision removes the most important sensory component of the foreskin - thousands of coiled fine-touch receptors called Meissner's corpuscles.

Most important? Who established this, and what was the study methodology?

Also lost are branches of the dorsal nerve, and between 10,000 and 20,000 specialized erotogenic nerve endings of several types.

What is the source for this number? Neither of the two cited sources support it. In fact, having researched this in some depth, I feel quite confident in stating that no study has ever counted the number of nerve endings in the foreskin.

Together these detect subtle changes in motion and temperature, as well as fine gradations in texture.
[1. R. K. Winkelmann, "The Erogenous Zones: Their Nerve Supply and Its Significance," Proceedings of the Staff Meetings of the Mayo Clinic 34 (1959): 39-47. 2. R. K. Winkelmann, "The Cutaneous Innervation of Human Newborn Prepuce," Journal of Investigative Dermatology 26 (1956): 53-67.]

Again, the sources fail to support the claims attributed to them.

The Frenulum[.] The highly erogenous V-shaped web-like tethering structure on the underside of the glans; frequently amputated along with the foreskin, or severed, either of which destroys its function and potential for pleasure.
[1. Cold, C, Taylor, J, "The Prepuce," BJU International 83, Suppl. 1, (1999): 34-44. 2. Kaplan, G.W., "Complications of Circumcision," Urologic Clinics of North America 10, 1983.]

Neither of the cited sources actually supports these claims. This isn't terribly surprising because a) the frenulum's potential for pleasure is speculative, and b) the function of the frenulum, such as it is, is to hold the foreskin in place over the glans. Without a foreskin, then, it has no function.

Muscle Sheath[.] Circumcision removes approximately half of the temperature-sensitive smooth muscle sheath which lies between the outer layer of skin and the corpus cavernosa. This is called the dartos fascia.
[Netter, F.H., "Atlas of Human Anatomy," Second Edition (Novartis, 1997): Plates 234, 329, 338, 354, 355.]

"Approximately half" is of course an exaggeration, but it is true that the foreskin does contain this layer.

The Immunological Defense System of the soft mucosa. This produces both plasma cells that secrete immunoglobulin antibodies and antibacterial and antiviral proteins such as the pathogen-killing enzyme lysozyme.
[1. A. Ahmed and A. W. Jones, "Apocrine Cystadenoma: A Report of Two Cases Occurring on the Prepuce," British Journal of Dermatology 81 (1969): 899-901. 2. P. J. Flower et al., "An Immunopathologic Study of the Bovine Prepuce," Veterinary Pathology 20 (1983):189-202.]

The cited sources utterly fail to support these claims. The second is not even a study of the human prepuce, but rather that of the cow! While the foreskin doubtless contains the immunological functions of any skin, no special mechanisms are known.

Lymphatic Vessels[.] the loss of which reduces the lymph flow within that part of the body's immune system.
[Netter, F.H., "Atlas of Human Anatomy," Second Edition (Novartis, 1997): plate 379.]

This is really scraping the bottom of the barrel, but yes, removing skin does remove the lymph vessels within it.

Oestrogen Receptors The presence of estrogen receptors within the foreskin has only recently been discovered. Their purpose is not yet understood and needs further study.
[R. Hausmann et al., "The Forensic Value of the Immunohistochemical Detection of Oestrogen Receptors in Vaginal Epithelium," International Journal of Legal Medicine 109 (1996): 10-30.]

If confirmed, for that matter.

[Indented box] The Body is Well Designed - Altering it Surgically can only Disrupt it's Natural Function

This is more a statement of faith than a serious claim, but we can transform it into a scientifically testable hypothesis: surgical alteration of the body cannot produce positive effects. It seems almost trivial to show that it is false.

The Apocrine Glands of the inner foreskin, which produce pheremones -nature's powerful, silent, invisible behavioural signals to potential sexual partners. The effect of their absence on human sexuality has never been studied.
[A. Ahmed and A. W. Jones, "Apocrine Cystadenoma: A Report of Two Cases Occurring on the Prepuce," British Journal of Dermatology 81 (1969): 899-901.]

A serious problem with this claim is that apocrine glands are absent in the inner foreskin. Amusingly, one of the sources cited above (Taylor et al) says this: "the mucosal surface of the prepuce is completely free of lanugo hair follicles, sweat and sebaceous glands". Similarly, Parkash et al report: "Multiple small pieces were taken from the inner lining of the circumcised prepuce [...] A special search was made for glandular tissue. No such tissue was found in the material".

Sebaceous Glands which lubricate and moisturise the foreskin and glans, normally a protected and internal organ-like the tongue or vagina. Not all men have sebaceous glands on their inner foreskin.
[A. B. Hyman and M. H. Brownstein, "Tyson's Glands: Ectopic Sebaceous Glands and Papillomatosis Penis," Archives of Dermatology 99 (1969): 31-37.]

In fact, according to the studies cited above, no men have sebaceous glands on their inner foreskin.

Langerhans Cells Specialised epithelial Langerhans cells, a first line component of the body's immune system in a whole penis.
[G. N. Weiss et al., "The Distribution and Density of Langerhans Cells in the Human Prepuce: Site of a Diminished Immune Response?" Israel Journal of Medical Sciences 29 (1993): 42-43.]

The cited source actually states the opposite: that the foreskin is deficient in Langerhans cells.

Colouration[.] The natural coloration of the glans and inner foreskin (usually hidden and only visible to others when sexually aroused) is considerably more intense than the permanently exposed and keratinized coloration of a circumcised penis. The socio-biological function of this visual stimulus has never been studied.

Ignoring the keratinisation error, this seems to be rather desperate. The appearance of the penis is changed, so this is a loss?

Some of the penis length and circumference because its double-layered wrapping of loose and usually overhanging foreskin is now missing, making the circumcised penis truncated and thinner than it would have been if left intact.
An Australian survey in 1995 showed circumcised men to have erect penises an average of 8mm shorter than intact men.
[1. R. D. Talarico and J. E. Jasaitis, "Concealed Penis: A Complication of Neonatal Circumcision," Journal of Urology 110 (1973): 732-733. 2. Richters J, Gerofi J, Donovan B. Why do condoms break or slip off in use? An exploratory study. Int J STD AIDS. 1995; 6(1):11-8. ]

It should be noted that this Australian study is in fact the only study to report such a difference.

Blood Vessels[.] Several feet of blood vessels, including the frenular artery and branches of the dorsal artery are removed in circumcision. This loss of the rich vascularity interrupts normal flow to the shaft and glans of the penis, damaging the the natural function of the penis and altering its development. [1. H. C. Bazett et al., "Depth, Distribution and Probable Identification in the Prepuce of Sensory End-Organs Concerned in Sensations of Temperature and Touch; Thermometric Conductivity," Archives of Neurology and Psychiatry 27 (1932): 489-517.� 2. Netter, F.H., "Atlas of Human Anatomy," Second Edition (Novartis, 1997): plates 238, 239.]

It is quite likely that several feet are lost, as the human body has an extraordinary number of blood vessels (a typical estimate is that the adult human body contains 100,000 miles of blood vessels). The claimed consequences, however, are unsupported by the references cited.

Dorsal Nerves The terminal branch of the pudendal nerve connects to the skin of the penis, the prepuce, the corpora cavernosa, and the glans. Destruction of these nerves is a rare but devastating complication of circumcision. If cut during circumcision, the top two-thirds of the penis will be almost completely without sensation. [1. Agur, A.M.R. ed., "Grant's Atlas of Anatomy," Ninth Edition (Williams and Wilkins, 1991): 188-190. 2. Netter, F.H., "Atlas of Human Anatomy," Second Edition (Novartis, 1997): plate 380, 387.]

One wonders why such extremely rare, albeit possible complications are included, then. To pad out the list, perhaps?

Complications Every year boys lose their entire penises from circumcision accidents and infection. They are then "sexually reassigned" by castration and "transgender surgery" and expected to live their lives as "females". [1. J. P. Gearhart and J. A. Rock, "Total Ablation of the Penis after Circumcision with Electrocautery: A Method of Management and Long-Term Followup," Journal of Urology 142 (1989):799-801. 2. M. Diamond and H. K. Sigmundson, "Sex Reassignment at Birth: Long-Term Review and Clinical Implications," Archives of Pediatrics and Adolescent Medicine 151 (1997): 298-304.]

It may be an exaggeration to claim that this happens "every year", but cases have been reported, unfortunately.

Death Every year many boys lose their lives from the complications of circumcision, a fact the billion-dollar-a-year circumcision industry in the U.S. routinely obscures and ignores.
[1. G. W. Kaplan, "Complications of Circumcision," Urologic Clinics of North America 10 (1983): 543-549. 2. R. S. Thompson, "Routine Circumcision in the Newborn: An Opposing View," Journal of Family Practice 31 (1990): 189-196.]

Again, death does occur, albeit rarely. However, it would be foolish to consider such deaths in isolation. They should be weighed against deaths attributable to lack of circumcision. That is, if a million boys are circumcised, does this result in more or fewer deaths than if those boys are not circumcised. The evidence indicates that lives are saved.

Emotional Bonding[.] Circumcision performed during infancy disrupts the bonding process between child and mother. There are indications that the innate sense of trust in intimate human contact is inhibited or lost.

Who established this, and what was the study methodology?

It can also have significant adverse effects on neurological development. Additionally, an infant's self-confidence and hardiness is diminished by forcing the newborn victim into a defensive psychological state of "learned helplessness" or "acquired passivity" to cope with the excruciating pain which he can neither fight nor flee.

Who established this, and what was the study methodology? (How on Earth would one be able to prove such a thing? It looks suspiciously like an unfalsifiable statement: a product of pseudoscience, not science.

The trauma of this early pain lowers a circumcised boy's pain threshold below that of intact boys and girls. [1. R. Goldman, Circumcision: The Hidden Trauma (Boston: Vanguard Publications, 1997), 139-175. 2. A. Taddio et al., "Effect of Neonatal Circumcision on Pain Responses during Vaccination in Boys," Lancet 345 (1995): 291-292.]

Neurological Sexual Communication[.] Although never studied scientifically, contemporary evidence suggests that a penis without its foreskin lacks the capacity for the subtle neurological "cross-communication" that occurs only during contact between mucous membranes and which contributes to the experience of sexual pleasure.

What utter nonsense! How on earth would non-scientific evidence suggest such a thing? This appears to be nothing more than a wild theory, dishonestly presented as something suggested by evidence.

Amputating an infant boy's multi-functional foreskin is a "low-grade neurological castration" [Immerman], which diminishes the intensity of the entire sexual experience for both the circumcised male and his partner.)

So prove it. Should be trivial. Except, of course, that scientific studies of satisfaction, etc., don't support this claim.